ارجو افادتى عن هذا التحليل الجديد il28b

السادة الاعضاء المتخصصين .......زممنون لكم مقدما
وارجو شرح هذا التحليل لانه ضرورى جدا

IL SNP assay
Test:
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Total genomic DNA from this patient was extracted and subjected to PCR - Restriction Fragment Length Polymorphism (PCR - RFLP)analysis and Resolved on Polyacrylamide Gel Electrophoresis.


result
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the above named patient harbors s CT geno type at IL 28b . rs 12979860 SNP located ~ 3kb upstream of the IL28b gene indicating moderate possibility to achieve sustained virological response (SVR) in response to a 48 week duration of peg IFN RBV combined therapy .
furthermore , CMV DNA was not detected indicating no viral reactivation
conclusion
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if the patient has F0/F1 he is expected to achieve SVR during or at the end of 48 week treatment . if the patient is F2-F4 a third drug (e.g. protease inhibitors or Amantadin) may be supplemented to ) may be supplemented to ifn rbv .

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